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Visible improvements often start within 412 weeks, with optimal results in 36 months

[1] These side effects typically emerge during dose escalation and often diminish over time, but for IBS patients with baseline constipation, the additional slowing of gut transit may prove problematic

Irregular dosing may lead to breakthrough symptoms

In practice, these differences are usually minor and fall within the range of individual variation, but they add a layer of uncertainty that pharmaceutical products do not have