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However, while these experiments did not distinguish which KCC may be involved in the stimulatory effects of high doses of the diuretic, inhibition of -cell KCC2 with highly selective drugs (Kursan et al., 2017) or its transient siRNA-mediated downregulation in islets (Pae and Harper, 2021) resulted in increased insulin secretion in response to glucose

A high-resolution sagittal T1-weighted (T1-w) 3D sagittal inversion recovery prepared spoiled gradient echo (IR-SPGR) scan was initially acquired for localization of the spectroscopy voxel (TR = 7.35 ms, TE = 3.04 ms, inversion time (TI) = 400 ms, field of view (FOV) = 270 mm, flip-angle = 11, matrix size = 256 256, slice thickness = 1.2 mm, 196 slices)

& Rice, G

Protein intake must support collagen synthesis: BPC-157 upregulates the machinery for collagen production, but collagen is made from amino acids