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Women taking GLP-1s for hot flashes may also experience: Improved Cardiovascular Health: GLP-1s are known for their heart-protective effects, reducing the risk of cardiovascular disease, which is particularly important as the risk increases after menopause

Similarly, expression of mutant TDP-43 in cellular, yeast, and Drosophila models increases markers of oxidative stress, including protein carbonylation and glutathione S transferase D1 (Duan et al., 2010

However, researchers have noted that the "GIP-heavy" profile of Retatrutide and Tirzepatide may actually blunt some of the more severe emetic effects seen with pure GLP-1 agonists

Structure and function of the healthy pre-adolescent pediatric gut microbiome