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It is downregulated in gastric and colorectal cancers but upregulated in lung adenocarcinoma and breast tumors compared to normal tissue ( In gastric and colorectal cancer, high CHAC2 expression leads to reduced glutathione, elevated intracellular Ca 2+ and increased ROS, resulting in inhibited tumor growth, proliferation and migration
Nature 575:688692 Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, Yang X, Fei J et al (2021) Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
About 35% were related to drug manufacturing facilities that failed to meet GMP standards
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