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Additional studies measuring cystatin (38,39), an alternative filtration marker less influenced by changes in body weight, would provide more insight about the effects of semaglutide on eGFR over time and to what extent serum creatininebased eGFR estimates are influenced by body weight changes

GLP-1 stands for glucagon-like peptide-1, a naturally occurring hormone involved in: Appetite regulation Blood sugar control Insulin secretion Digestion Feelings of fullness A GLP-1 receptor agonist treatment mimics the effects of this hormone, helping individuals feel satisfied with smaller amounts of food while supporting healthier blood sugar regulation

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