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Enhanced Efficacy with Dual-Action Medications: Newer agents like tirzepatide, which target both GLP-1 and GIP receptors, have often demonstrated superior blood sugar lowering and more significant weight loss in clinical trials compared to GLP-1 RAs that only target one receptor

June 2024: Structure Therapeutics reported positive Phase IIa obesity data for GSBR-1290, an oral non-peptide small-molecule GLP-1 receptor agonist, achieving 6.2% placebo-adjusted mean weight loss at 12 weeks

Prior research from Virta had shown similar weight loss results for people who had never started GLP-1 drugs compared to those who do take GLP-1 medications