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The initiation of insulin is recommended when severe hyperglycemia (more than 9% HbA1c) is detected at diagnosis, especially if hyperglycemic symptoms (polyuria or polydipsia) or any catabolic features (weight loss or ketosis) are present

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Applying a fraud guideline, the district court calculated a $32 million loss based on the $2 street price paid by end users, and the Sixth Circuit agreed that street-level buyers were the intended victims

[9] It is a first-line therapy for acute uncomplicated cystitis