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Additionally, oxidatively modified HMGB1, along with ROS and myeloperoxidase (MPO) released by neutrophils, can promote the formation and rupture of atherosclerotic plaques, thereby accelerating the progression of cardiovascular disease [243]

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The recommended dose in rabbits (0.010.05 mg/kg) is the same for intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration, despite lack of pharmacokinetic data