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However, with no prospective randomized controlled trials (RCTs) for either therapies or approaches (NBS programs) and very low numbers of affected individuals, assigning letter grades of literature evidence quality is difficult

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Enhanced expression of GSH metabolism enzymes including glutathione peroxidases, gamma-glutamyl cysteinyl synthetase (gamma-GCS), glutathione S-transferases (GST), and ABC-family membrane transport proteins including the multidrug resistance-associated protein (MRP) were all documented to play prominent roles in cellular resistance to oxidative stress

This is a great approach because it is unbiased and doesnt require any previous knowledge or guessing