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24 As a result, there is a reduction in the atherosclerotic plaques macrophage-associated inflammation

Remarkably, NAC has significantly higher anti-inflammatory efficacy than Aspirin and Minocycline, easily passes bloodbrain barrier (BBB), and inhibits TNF, IL-1, and IL-6 [130]

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This suggests that a resistance exercise-related mechanism of inducing plasma NO, perhaps due to increased shear stress that triggered an up-regulation in NO-cGMP signaling along with a slow, sustained release of NO from GSH + CIT, may be a conceivable candidate for this response