Continuous vigilance is critical for monitoring potential side effects
GLP-1R overexpression can inhibit the expression of inflammatory factors such as IL-6, IL-8, TNF- and granulocyte and macrophage colony-stimulating factor (GM-CSF) by increasing the expression of adenosine triphosphate-binding cassette transporter A1 (ABCA1) and reduce the proliferation and migration of smooth muscle, indicating that GLP-1R can play a protective role in smooth muscle cells and COPD, thereby improving airway inflammation and airflow limitation in COPD patients, providing a basis for the application of GLP-1RA in COPD
That matters because weight loss does not necessarily equate to better health, especially if too much of that loss comes from the muscle
Their potential is only realized if patients can afford and access them, said Ezekiel Emanuel, MD, PhD, vice provost for Global Initiatives, co-director, Healthcare Transformation Institute, University of Pennsylvania and senior author on the paper