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doi: 10.1016/j.scitotenv.2022.157861 10 ZhangAMatsushitaMZhangLWangHShiXGuHet al
The following points highlight the positive outcomes associated with GH increase in adults: Body Composition Improvement: GH replacement therapy induces an increase in lean body mass and a decrease in fat mass
Documented mechanisms relevant to skin ageing include: COL1A1 and COL3A1 transcriptional upregulation in dermal fibroblasts (multiple independent groups) MMP-2 and MMP-9 regulation (balanced remodelling rather than pure degradation) TIMP-1/TIMP-2 upregulation maintaining MMP-TIMP homeostasis Hyaluronan synthase (HAS1/HAS2) upregulation improving dermal hydration biology Fibronectin and decorin production for ECM structural integrity Epidermal keratinocyte migration and proliferation (scratch assay, organotypic skin model data) Epitalons dermal relevance is primarily indirect via melatonin restoration (melatonin has photoprotective and anti-photoageing activity in skin) and systemic antioxidant effects rather than direct fibroblast or keratinocyte biology
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