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In some embodiments, the otic formulation or composition comprises about 0.06% by weight of the poloxamer

Premature graying is often linked to an accumulation of hydrogen peroxide and oxidative stress within the hair follicle, which "bleaches" the hair from the inside out

it was found that the severity of the infection was lower in mice pre-treated with L.casei /pPG612.1-BLF intra-vaginally than in the control

Comparison With Minoxidil A well-cited comparative study reported that the compound produced hair follicle enlargement effects comparable to minoxidil in animal models, while displaying a different side effect profile