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Oral GLP-1s for obesity saw a recent setback when in April (April 2025), Pfizer announced that it was discontinuing development of danuglipron, an oral GLP-1 receptor agonist, which was being investigated for chronic weight management, due to potential liver toxicity

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The advanced stage of diabetic retinopathy occurs due to retinal neovascularization, the development of new and abnormal blood vessels in the retina, which are prone to leak fluids and blood

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