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These findings were further supported in a murine model fed a Western diet and treated with CCl 4 (89)

A consistent rhythm of three to four sessions per week is often more beneficial than pushing for marathon sweats

Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)