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A novel platinum complex containing a piplartine derivative exhibits enhanced cytotoxicity, causes oxidative stress and triggers apoptotic cell death by ERK/p38 pathway in human acute promyelocytic leukemia HL-60 cells

As ACSL4 gains traction as a therapeutic target in oncology, its role in activating the ferroptosis mechanism presents a novel strategy for treating tumors, especially those resistant to conventional chemotherapy or adept at evading apoptosis [43]

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