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Abstract Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females

CD4 + T cells produce and secrete higher levels of succinic acid, upregulating HIF-1, which further affects their metabolism and function, including promoting inflammation and immune response (44, 75, 101, 154)

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