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For type 2 diabetes trials applying typical criteria (age 1875 years, BMI 25 kg/m 2 , HbA1c 7.010.0%, eGFR 30 mL/min/1.73m 2 ), final eligibility was uniformly low across populations: 4.1% for Non-Asian US, 1.5% for Asian US, and 2.1% for Korean adults, with the HbA1c requirement representing the primary exclusion criterion