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Synthesis of D-P H-His(Trt)-OMeHCl (5.0 g, 11.15 mmol), Boc-Gly-OH (2.15 g, 12.25 mmol), HATU (8.5 g, 22.35 mmol) and HOAT (3.0 g, 22.35 mmol) were dissolved in DMF (80 mL) under nitrogen atmosphere and ice bath conditions

Es fundamental destacar que el uso off-label de estos medicamentos debe realizarse bajo supervisin mdica estrecha, con una evaluacin integral que considere la salud mental del paciente, el riesgo de efectos adversos, y la necesidad de un enfoque multidisciplinario que incluya apoyo psicolgico y nutricional

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