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They target tumor cells for destruction and are also vital for responding to viral infections by destroying infected cells.[ref] Calcium ions play numerous roles in the activation of different cellular processes

doi: 10.1074/jbc.C300063200 60 BatterhamRLCowleyMASmallCJHerzogHCohenMADakinCLet al

However, due to experimental constraints, the concentration of metformin used was relatively high, making it challenging to apply in clinical treatments for patients [28]