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As different APOE genotypes are shown to have different energy substrate preferences it is not surprising that L-carnitine administration affected levels of these FAO metabolites differently by genotype ( Several sex effects were also observed throughout these studies, where despite higher levels of total plasma acylcarnitines in females compared to males, in aging females, there was a significant decrease in total acylcarnitines which was not seen in aging males, indicating that aging may impact female peripheral lipid bioenergetics more than males