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Back in 2010, the US Food and Drug Authority (FDA) concluded that increases in the incidence of carcinomas among rodents translated into a low risk for humans, because statistically significant increases occurred only at drug-exposure levels many times those anticipated in humans

American journal of physiology Heart and circulatory physiology

After 2012, losing a formulary negotiation meant no coverage at all

Red flags requiring urgent evaluation include new focal weakness, gait disturbance, bowel or bladder dysfunction, rapidly progressive symptoms, or fever in immunocompromised patients