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Willoughby) that was published in 2015

L.ChenI.-M.LeeM.-S.ChuangL.-C.et al

In hyperuricemia, uric acid is supersaturated in urine and forms uric acid crystals, which are transported to lysosomes by the endocytosis of renal tubular epithelial cells, destroying the lysosomal membrane and causing lysosomal rupture, in turn, resulting in renal inflammation 20