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Validating urine-based biomarkers (e.g., glomerular cell-derived exosomal ferroptosis regulators, and 4-HNE metabolites) or circulating signatures that correlate with IgA nephropathy disease activity, pathological severity, or response to interventions is urgently needed to guide clinical trial design and patient stratification

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Muscle Safety: Myalgia and Rhabdomyolysis Risk Patients starting Zepbound while already on rosuvastatin sometimes report new-onset muscle aches and wonder whether the combination caused it

These are prescription decisions that require provider evaluation and monitoring