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This mechanism is similar to that of GLP-1 receptor agonists, but without the associated side effects

Specifically, exenatide treatment over 48 to 60 weeks increased tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1) in neuronal-derived extracellular vesicles (exosomes), alongside activation of downstream signaling proteins such as total Akt and phosphorylated mTOR [61]

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Using Phentermine After GLP-1s: Transition Plans and When It Helps Most Phentermine can play a valuable role after stopping GLP-1 medications such as semaglutide or tirzepatide, particularly for patients experiencing hunger rebound