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Therefore, the use of ICEMAN to assess the subgroup effects of the above outcomes was not applicable

However, long-term data on the specific four-peptide combination is limited

Clin J Am Soc Nephrol: CJASN

10.2 Mechanisms and epidemiology Nociplastic pain stems from central sensitization, involving abnormal pain processing in the peripheral and central nervous systems, leading to increased sensitivity and reduced inhibition