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Red flags requiring urgent assessment include rapidly progressive unilateral swelling (consider deep vein thrombosis or cancer recurrence), acute cellulitis with systemic features (requiring immediate antibiotic therapy), or new masses in the affected area

Expert Rev Gastroenterol Hepatol 13(8):739749 Neag MA, Mocan A, Echeverra J, Pop RM, Bocsan CI, Crian G, Buzoianu AD (2018) Berberine: Botanical occurrence, traditional uses, extraction methods, and relevance in cardiovascular, metabolic, hepatic, and renal disorders

Duncan, J