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Following granule exocytosis, perforin facilitates the delivery of granzymes into the cytosol of the target cell where they cleave numerous substrates, including caspases, resulting in the rapid induction of apoptosis 7,8

3.1.3 Phospholipid oxidation products and inflammatory signaling Oxidized phospholipids generated through peroxidation, such as hydroxylated lipids and keto-lipids, not only compromise the integrity of the cell membrane directly but also increase membrane tension in tandem with enhanced lipid peroxidation