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A 2015 review in the Journal of Clinical Endocrinology confirming that GHRH analogs combined with ghrelin-pathway agonists produce a synergistic GH secretory response that exceeds additive effects when either compound is used alone provides the mechanistic basis for why combination therapy is the standard in supervised clinical settings

Other data generated are available from the corresponding author upon reasonable request

Abstract Oxidative stress, disrupted copper homeostasis, and neuroinflammation due to overproduction of proinflammatory cytokines are considered leading causative factors in development of age-associated neurodegenerative conditions

Springer, New York, pp 123 Page M, Sultana N, Paszkiewicz K, Florance H, Smirnoff S (2012) The influence of ascorbate on anthocyanin accumulation during high light acclimation in Arabidopsis thaliana : further evidence for redox control of anthocyanin synthesis