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Shaking rather than gently swirling, using non-sterile water, or injecting directly onto the powder cake can all reduce effectiveness

0.25 mg per injection Weeks 1 4 Frequency 1 / week Monthly Total 1.0 mg Purpose GI adaptation 0.25 mg/wk 0.5 mg per injection Weeks 5 8 Frequency 1 / week Monthly Total 2.0 mg Purpose Dose escalation 0.5 mg/wk 1.0 mg per injection Weeks 9 12 Frequency 1 / week Monthly Total 4.0 mg Purpose Therapeutic range 1.0 mg/wk 1.7 mg per injection Weeks 13 16 Frequency 1 / week Monthly Total 6.8 mg Purpose Continued escalation 1.7 mg/wk 2.4 mg per injection Week 17 onward Frequency 1 / week Monthly Total 9.6 mg Purpose Maintenance dose 2.4 mg/wk Pick Your Injection Day Cagrilintide is injected once per week on the same day

They may also be preferred in patients with elevated glycemia levels and high BMI aiming at modifying CV risk factors (2)

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