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GLP-1 coverage cuts: What shifting payer policies mean for prescribing, access, and utilization Feb 18th, 2026 Glucagon-like peptide-1 (GLP-1) receptor agonists like semaglutide (sold under brandnames Wegovy and Ozempic) and tirzepatide (Zepbound, Mounjaro) have transformed how physicians and patients approach treatment for type 2 diabetes and obesity

It combines a Growth Hormone Releasing Hormone (GHRH) analog with a Growth Hormone Secretagogue (GHS), creating a much more potent and physiologically natural response than either compound could on its own

Figure 1 Figure 2 Accordingly, DPP-4 can be viewed as a multi-functional protein with a spectrum of actions which go beyond its role as a proteolytic enzyme