Results: GHK-Cu alleviated weight loss, improved the disease activity index (DAI), reduced colonic edema and shortening, attenuated inflammatory damage, increased goblet cell numbers, suppressed inflammatory cytokines such as TNF-, IL-6, and IL-1, and promoted mucosal repair
This improved sensitivity works synergistically with Retatrutides direct effects on insulin secretion and action
Acknowledgements This study was supported by Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital for facilities, and with the grant support of the Ministry of Science and Technology, TAIWAN, under grants nos 104-2221-E-182-034, 104-2314-B-039-058,104-2314-B-039-058, 105-2221-E-182-022, 105-2221-E-182-022, 105-2923-B-002-001-MY3, Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW107-TDU-B-212-113004), and by Chang Gung Memorial Hospital, TAIWAN, under grants nos CIRPD2E0051-53, CMRPD2D0111-13, and CMRPG3D1061-3
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