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Researchers have found especially strong correlations between chronic constipation and two chronic neurological diseases: Parkinsons disease and Lewy-body dementia (in which abnormal protein deposits called Lewy bodies build up in brain cells) (Idiaquez 2011

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In our recent preclinical studies, dual inhibition of IDO1 and TDO2 with the novel agent AT-0174 effectively reduced KYN levels, increased tumor infiltration with natural killer cells, and reduced regulatory T cells in cisplatin-resistant lung cancer models (38)

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