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Furthermore, IS activates NF-B signaling, increasing pro-inflammatory factors such as cyclooxygenase-2, ROS, TNF-, IL-6, and IL-1, while suppressing antioxidant factors such as heme oxygenase-1 and superoxide dismutase 2, through Nrf2 pathway inhibition, thereby disrupting intestinal homeostasis and promoting systemic inflammation in mice ( Figure 3 ) [116]

As the reaction time increased, the resulting QDs absorption band red shifted gradually to longer wavelengths and the final product gave an absorption band with max at 553 nm after heating for 115 minutes (Table 1)

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