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Thymol mitigates the reduction of trans-epithelial electrical resistance (TEER) in a porcine IPEC-J2 monolayer cell model stimulated with LPS by increasing ZO-1 and actin expression ( Along with improving barrier function, thymol can decrease the production of ROS and the expression of pro-inflammatory cytokines following stimulation with LPS (214) and in colonic homogenates in murine colitis (215)

Histamine also acts as a hormone regulator and helps keep us awake during the day, supports gut motility and gastric acid production, and contributes to feelings of satiety when we eat

Interestingly, although the TG level in the hypothyroid blood was higher and none of the patients was overweight (average BMI was 17.0 4.4 kg/m 2 ), and the findings indicate that the deposition of TG might not have occurred at a significant level in the adipose tissues