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Since one works centrally and the other peripherally, combination therapy might help men who get partial responses from each alone

Both agents can enhance glucose-dependent insulin secretion, reduce glucagon secretion, and delay gastric emptying [Reference Chiappini, Vickers-Smith, Harris, Papanti Pelletier, Corkery and Guirguis43Reference Knudsen and Lau45]

Additionally, semaglutide slows gastric emptying, prolonging the sensation of fullness and reducing the frequency of hunger signals

Weight gain is not simply caused by overeating hormones, insulin resistance, metabolism, genetics, stress, and appetite regulation all play important roles