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Because unbound drug concentration is determined by dosing rate and clearancewhich is not altered, in the case of these low-extraction-ratio drugs, by protein bindingincreases in dosing rate will cause corresponding changes in the pharmacodynamically important unbound concentration

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No significant difference in food intake was observed between treated and control mice in related studies, indicating that its antiobesity effect mainly depends on regulating fat metabolism rather than suppressing appetite - a unique advantage in obesity research