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Updated multi-society guidance aligns with broader recommendations which prioritize individualized risk factors for aspiration and other complications, rather than dosing frequency alone

In addition, the trigeminal nerve, which innervates both the respiratory and olfactory regions, provides a direct anatomical pathway from the nasal cavity to the brainstem and olfactory bulb (Johnson et al., 2010)

Ongoing and future studies should aim to delineate the detailed inflammatory pathways involved in OA, providing a foundation for the development of safer, more efficacious antiinflammatory therapeutics and consequently improving patients overall quality of life 11

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