It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation
Peptides can interact with anaesthetic, anti-inflammatory, and blood thinning medications
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In a laboratory setting, it is utilized as a highly targeted biochemical tool to study how specific peptide sequences interact with cellular repair mechanisms