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(viii) suppression of de novo lipogenesis after decreasing fatty acid synthase and acetyl-CoA carboxylase 1 expression and (ix) reduction of insulin/glucagon ratio that results in almost 25% restriction of glucose utilization and enhanced ketogenesis

The third term is the loss of cysteine in the reaction catalyzed by GCS that makes glutamyl-cysteine and the fourth term represents the loss of cysteine to other pathways (for example to sulfate and taurine)