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Acknowledgments and Funding The authors would like to thank the University of Iowa Viral Vector Core and Central Microscopy Research Facility for technical assistance

A 2025 pilot study published in Headache: The Journal of Head and Face Pain found that liraglutide - a GLP-1 closely related to semaglutide - reduced average monthly migraine days from 19.8 to 10.7 in patients with chronic migraine unresponsive to at least two prior preventive treatments

As the long-acting (more potent) GLP-1 RAs liraglutide, semaglutide and dulaglutide [1, 2] are becoming the standard in treatment, we focused on these agents

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