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Wong, PhD, MPH, a professor of medicine at the University of California, Irvine School of Medicine, and colleagues noted that the impact glucagon-like peptide 1 (GLP-1) receptor agonists have on weight loss have recently generated interest and investigation. Semaglutide activates GLP-1 receptors, improving incretin function and insulin secretion (glucose-dependent), inhibiting glucagon release and suppressing hepatic gluconeogenesis, resulting in reductions in both fasting as well as postprandial glucose, they wrote in Cardiovascular Drugs and Therapy

This article explores evidence-based approaches to managing fatigue during GLP-1 therapy whilst ensuring safe, effective treatment outcomes

By mid-week, both the nausea trigger and the B6 protection diminish together

GLP-1 slows gastric emptying (food stays in your stomach longer), increases satiety (you feel fuller faster), and reduces appetite