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With the combination of Cu(II), glycyl-L-histidyl-L-lysine-Cu 2+ (GHK-Cu) improves antioxidative and anti-inflammatory bioavailability, and they might offer potential therapeutic properties for COPD

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Lancet 2021;397:173648.ArticlePubMed 101

However, their effectiveness on their own is limited, especially for older marks, because they struggle to penetrate deep enough into the skin