History of pancreatitis Severe gastrointestinal disease Gallbladder disease or a history of cholelithiasis Pregnancy or breastfeeding Concomitant use of insulin or insulin secretagogues (e.g., sulphonylureas), which may increase hypoglycaemia risk Retatrutide, like other incretin-class medicines, may slow gastric emptying, which can affect the absorption of oral medicines taken at the same time
Edvardsson VO, Goldfarb DS, Lieske JC, Beara-Lasic L, Anglani F, Milliner DS, et al
They may include: Mild nausea, vomiting, or diarrhea Constipation Abdominal pain or discomfort Headache These effects are usually short-lived and can often be minimized by ensuring you are well-hydrated, by adjusting your diet (e.g., avoiding fatty foods, eating smaller meals), and by gradually increasing your dose as advised by your provider
This disconnect is more common than most TRT patients are told, and the explanation lives further