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It is well established that when the liver is injured as a result of introduction of infectious agents or chemicals, the serum levels of GPT (ALT) and GOT (AST) are raised significantly [26], along with leakage of ALP and LDH [27] reflecting the severity of liver injury [28]

Bucher et al., 1990)

Topical prescription agents such as hydroquinone, retinoids, azelaic acid, or tranexamic acid are applied directly to affected areas and are used under medical supervision to influence pigment production and skin renewal processes

This suggests that the development of genomic instability is a key event in melanomagenesis, potentially facilitating allelic imbalances that support maintenance and progression of disease