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For others, it may take several days or even a few weeks to experience the full effects, as your body gradually rebuilds its B12 stores and enhances red blood cell production

Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication

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even reviewed clinical observations of behavioral, affective and cognitive features already 20 years ago and hypothesized that atypical depression is a secondary symptom in chronic fatigue syndrome [140]