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Overall, lipid metabolism can have dual effects on neutrophil survival, and the purpose of lipolysis and lipogenesis in neutrophils varies considerably in the contexts of different diseases ( Figure 2 )

(2023, December 14)

At the systemic level, GLP-1 RAs improve insulin sensitivity in peripheral tissues (muscle, adipose), reduce circulating free fatty acid flux to the liver, suppress hypothalamic appetite circuits to promote weight loss, and lower systemic pro-inflammatory cytokines (TNF-, IL-1, IL-6), thereby reducing the hepatic inflammatory milieu indirectly [7,26,30]

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