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(PubMed) Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC

For most compounded versions of Semaglutide, however, the more common 120-day stability period applies, especially when stored at the recommended refrigeration temperature

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Its worth noting that the evidence here is evolving: a 2025 AAOS study found that a 14-day hold before total joint arthroplasty was the threshold needed to eliminate independent risk for delayed emergence and aspiration complications, suggesting the one-week ASA guidance may not be sufficient for orthopaedic procedures