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Furthermore, a recent clinical study in women with obesity treated with semaglutide showed improved recognition of basic tastes, altered gene expression in the tongue (measured by tongue biopsy), decreased activation of putamen in response to calorie-dense sweet and savory food cues, and increased cortical brain activity in response to the sweet taste stimulus compared to placebo

But the TGA does not recommend patients stop treatment without first consulting a doctor, nor has it placed new restrictions on prescriptions

The public comment period closes June 29, 2026

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist