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Big Pharma has lost trust due to overcharging for drugs and overmarking products leading to harm, like Vioxx 20 years ago
Approval status is night and day: tirzepatide is FDA-approved (Mounjaro in 2022, Zepbound in 2023), while retatrutide is still working through Phase 3
Expert consensus strongly advises against using such combinations outside of controlled research settings, primarily due to the unknown potential for adverse interactions, additive side effects, and unpredictable metabolic responses
Injectable GLP-1 therapies, particularly semaglutide and liraglutide, have well-established cardiovascular benefits
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